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Integrated analysis and targeting of oncogenic drivers and the anti-tumor immune response to improve outcomes and personalize therapy across the melanoma continuum

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They release a cocktail of signaling molecules including TNF-alpha, interleukin-1, interleukin-6, bone morphogenetic proteins (BMPs), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta), and vascular endothelial growth factor (VEGF)

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Sleep timing affects both therapies